|
|
Effects of gluten-free diet on immune parameters in Parkinson's disease
Jandová, Mônica ; Funda, David (advisor) ; Dobeš, Jan (referee)
Tato studie zkoumá možné, i malé, vlivy bezlepkové diety v porovnání se standardní dietou na rozvoj Parkinsonovi nemoci s využitím 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridinem (MPTP) indukovaném myším modelu Parkinsonovi nemoci, a samců kmene C57Bl6. Tento výzkum zahrnuje zavedení jak akutního tak chronického myšího MPTP modelu, a řadu navazujících flow cytometrických analýz zaměřených na regulační T buňky, cytokiny - interleukin 10 (IL-10) a interferon gama (IFN-), gamma/delta T buňky, a NK buňky ve slizničních a sytémových lyfatických orgánech. Pro posouzení vlivu na chování jse použili test otevřeného pole, který nám umožnil posoudit lokomotorickou aktivitu a explorativní chování myší v závislosti na podávané dietě. Dále jsem použili také imunofluorescenční barveni pro validaci efektu MPTP, které nám poskytlo vizuální potvrzeni neuroanatomických změn indukovaných neurotoxinem. První výsledky naznačují malé ale slibné známky pozitivních efektů bezlepkové diety. Nicméně tyto změny lze pouze opatrně interpretovat, protože je potřeba opakovaných a podrobnějších experimentů k posouzení zazanmenaných efektů. Spojení behaviorálních testů, imunohistologie a imunologických analýz představuje vícečetný metodicky přístup k této problematice, který nám může poodhalit komplexní interakce diety, střeva,...
|
|
|
How social networks affect celiacs'diets
Pretlová, Anna ; Háša, Marek (advisor) ; Hájková, Karolína (referee)
This paper examines the influence of social networks on the diet of celiacs. The aim was to investigate how social networks, specifically Facebook, Instagram, YouTube, Twitter and Pinterest, can influence the preparation, purchase and consumption of gluten-free products. The chosen research method was quantitative analysis. Results were obtained from Czech and a few Slovak celiacs and people with gluten allergy with help of a questionnaire survey followed by descriptive analysis. The questionnaire itself was disseminated on the social networks Instagram, Facebook and WhatsApp. The final sample included 264 from the original 279 respondents. The results show that the use of social networking sites is popular among patients with celiac disease and gluten-free diets and that users benefit from it. It was also revealed that the most useful social networks are Instagram amd Facebook. On the other hand, YouTube, Twitter and Pinterest fell completely in the evaluaion. The main reason for this is the small amount of beneficial information. When it comes to eating, celiacs are mainly looking for new recipes, products and places that offer gluten-free meals, according to the results. In addition to extend dietary horizons, social networks have also provent to contain important information about the disease...
|
|
|
Screening of probiotics bacterial strains aimed at proof of gluten degradation
Korvasová, Lucie ; Obruča, Stanislav (referee) ; Ryšávka, Petr (advisor)
No other treatment for celiac disease and other gluten-related disorders has been found so far except for a lifelong diet, which is significantly restrictive for the patient. Moreover, it is not always possible to adhere strictly to this diet, mainly due to random gluten ingestion, which leads to health complications associated with these diseases. Currently, vaccination is being tested as an alternative treatment, and there is also increasing attention paid to enzymes that could break down the immunogenic part of gluten, specifically in its gliadin component. This thesis examined bacteria that could potentially break down this sequence in gliadin and thereby reduce its concentration during detection. A considerable proportion of the tested bacteria belong to probiotics to ensure their future use for humans is safe. To obtain data, the fact was utilized that as bacteria grow, the turbidity increases proportionally, which was subsequently detected to determine the amount of bacterial growth. The RIDASCREEN® Gliadin competitive kit was used for the gliadin detection test, which works on the principle of a competitive ELISA method with R5 antibodies. The result of the study was the finding that only the bacteria Bacillus subtilis was able to break down gliadin among the examined bacteria. It was also measured how much gliadin the bacteria could break down at different concentrations, and according to the data, it was evaluated that it is appropriate to adapt the culture to the presence of gliadin for a greater amount of broken gliadin.
|
|
|
Potraviny pro zvláštní výživu-potraviny pro osoby s nesnášenlivostí lepku
Klusová, Petra
The aim of this bachelor thesis is to provide an overview of the topic Food for special nutrition, food for people with gluten intolerance. In the thesis, I focus on the labeling of gluten-free food and its nutritional value in comparison with food containing gluten. Among the gluten-free food we count those which contain more than 10 mg of gliadin per 100 g dry weight. The composition and labeling of gluten-free food is regulated by Commission Regulation (EC) 41/2009. Further, I focus on the origin of celiac disease, its development, symptoms and treatment. Celiac disease is caused by toxic effect of gluten particles, alpha gliadin. The body forms antibodies that affect enterocytes that are present in the lining of the small intestine.
|
|
|
Intolerance lepku a její dopad na lidský organismus
Sedláková, Simona
Bachelor thesis The Gluten Intolerance and Its Influence on Human Body focuses on the problem of celiac disease. It is an autoimmune disorder which is caused by gluten and its storage proteins. Gluten is responsible for the damage of the small intestine in people who are genetically predisposed to the celiac disease. The damaged intestine cannot fully absorb the nutrients, which induces the malabsorption syndrome in the body and leads to hypovitaminosis. New findings in the research of celiac disease show the connection of celiac disease with disorders such as autism, schizophrenia, depression, etc. The health conditions of the patients with these disorders, as well as with the celiac disease, can be significantly improved when the patient follows a gluten-free diet, which is the only freely available treatment so far. However, there should be new methods of treatment available in the next few years. The new methods of treatment would include enzyme supplements, the injections of larazotide acetate, suitable probiotic preparations and also cereals that would contain less toxic peptide components of gluten.
|
|
|
Awareness of general nurses about the treatment of celiak disease
HOLEJŠOVSKÁ, Petra
Abstract Objective: The bachelor's thesis deals with the awareness of general nurses about the treatment of celiac disease. The first chapter of the theoretical part is focused on the digestive system, small and large intestine. The following chapter is devoted to the definition of celiac disease, its history and clarification of the concept of gluten. The next chapter presents the symptoms, diagnosis and treatment of celiac disease and the health risks associated with it. The fourth chapter is devoted to gluten-free foods, their labeling, basic rules for buying gluten-free foods and preparing gluten-free food. The fifth chapter is focused on the contributions of health insurance companies to gluten-free food. The following chapter deals with the hospitalization of a celiac in a medical facility and provides some tips for hospitalization. The last chapter of the theoretical part deals with education, the role of the general nurse in the education of patients with celiac disease, forms of education and lists the most common myths associated with celiac disease. In the empirical part, the first goal was to map the awareness and knowledge of general nurses about celiac disease, its symptoms, manifestations and treatment. The second goal was to map the specifics of nursing care for patients with celiac disease. Method of achieving the goal: The set goals were achieved through a research survey, which was carried out using a qualitative approach, the method of questioning. The method of semi-structured interview was chosen for data collection. The examined group consisted of eight general nurses working in inpatient departments at the Tábor Hospital, a.s. Scientific benefits of the work: The research shows that general nurses have awareness and knowledge of celiac disease, its symptoms, manifestations and treatment, although the answers to some questions were only partial, sometimes inaccurate and in minimal cases incorrect. The identified specifics of nursing care for celiacs can be used in hospital facilities to improve the quality of care provided. Furthermore, the work can be used by people who are interested in obtaining information related to celiac disease and a gluten-free diet. Acquired knowledge and conclusions: The research survey revealed the specifics of nursing care for people with celiac disease, which are mainly associated with the gluten-free diet provided. Furthermore, celiac disease has been found to be incorrectly associated with allergies.
|
|
| |
|
|
Quality of patients life with celiac disease
Bičíková, Michaela ; Křivková, Jana (advisor) ; Vlachová, Marie (referee)
This thesis is dealing with the quality of life of patients with celiac disease. In the theoretical part, I am presenting the characteristics of celiac disease and I am describing its history briefly. For better orientation in the issue, I also joined a description of the anatomy of the small intestine and pathophysiology of celiac disease. In this thesis I am also dealing with incidence of disease, etiology and risk factors participating in the development of celiac disease, symptoms and the different forms, which are related to celiac disease, as well as potential complications and prognosis of celiac disease. An irreplaceable is the role of nurses in diagnosis and targeted screening for celiac disease, therapy and prevention, dispensarization and education of patients with celiac disease about gluten-free diet. I am also describing the problems that patients with celiac disease may encounter in everyday life. Last but not least I am focusing on the general concept of quality of life and also on the quality of life related to health and celiac disease. In the practical part, I am presenting aims and operational hypothesis, methodology of thesis and the characteristics of surveyed population sample. Chapter called the analysis of results includes pie charts showing the questionnaire's items,...
|
|
| |
|
|
Food intolerance
Jirkovská, Magdaléna ; Tlaskalová - Hogenová, Helena (advisor) ; Křížan, Jiří (referee) ; Seifertová, Eva (referee)
This bachelor's thesis is a literature research that deals with food intolerances. It focuses primarily on celiac sprue, describes the disease, its clinical manifestations, symptoms, complications, methods of investigation, diagnosis and treatment. Part of the thesis deals with relationship of gluten to other diseases such as gluten sensitivity or autism.
|
guest ::
